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KMID : 0374019850080040151
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Ewha Medical Journal
1985 Volume.8 No. 4 p.151 ~ p.160
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A Study of Effect of Recirculation in Experimental Cerebral Ischemia
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Abstract
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Focal cerebral ischemia initiates a serief, of events from the regional development of -ischemic edema, loss of neural functior´, and culminating in eventual infarction. The purpose o´f this study :is to determine the effect of recirculation in acute focal cerebral ischemia. Sixty adult mongrel cats of either sex underwent production of focal ischemia by transorbital occlusion of the left middle cerebral artery with a Heifetz clip.
The ´duration of ischemia was 1, 3 and 5 hours. In 5 animals in each group, the ischtmic brain was reperfused for 1A and 7 hours by removing the clip from the
artery. It -was observed that provided the restoration-of cerebral blood flow in cats - can be accomplished within 1 hour in cats or at least within 3 hours of the in-
cult, the reversal of the neurological deficits and prevention of irreversible cerebral infarction can be expected. Therefore the prevention of cerebral infarction must first be directed toward improving blood flow during the insult as rapidly as possible to minimize the time that cerebral blood flow is below threshold for the formation edema.
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